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I'm having problems with Sanitarium. The cursor flickers and leaves trails, which makes the game nigh unplayable for me.
One solution that I could find online was to change the compatibility mode to Win98. This did not work for me. I also tried for force Vsync off (worked for MechCommander, which had a similar issue), but to no avail.

I'm running WinXP Sp3 on a p4 3.2ghz, 3gb ram and an Nvidia GeForce 8600GTS, and my drivers are up to date.
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Same problem here. Also running WinXP Sp3. GeForce GT430, AMD Phenom II X2 550.
I've also got this problem. Running it on Win7.

Edit: Change the compability to Win95 and it fixed the problem
Post edited August 12, 2012 by HARDPUNCHER