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As per the title the menu keeps scrolling upwards and I can't interact with anything, not even the exit option.

I did get this game free from GOG.

One other thing I did try was unplugging all my input devices one by one and plugging them back in one by one to isolate the issue and that did nothing nor did rebooting the computer.

How do I fix this?

Thanks in advance,

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Same problem here.

No chance to play the game.

From here:
How do I fix the menu selection automatically scrolling through the options at fast speed?

Saints Row 2 has this issue with certain USB devices which it mistakenly thinks are game controllers. The first thing to try is to unplug all USB devices except your keyboard and mouse and see if that fixes it. Also, certain Saitek keyboards install their own HID-Compliant Game Controller entry in Device Manager to enable extra functionality like keystroke macros. Temporarily disabling this device in device manager could also fix the issue.