Mrakainus: I'm not sure what's going on, but suddenly, I can't pick up items, which sucks for certain quests, and I can't use Combat Arts. What do I do?
OK, it's been six years, but I reinstall Sacred at least every two years anyway and every single time I find this same page because of this same problem, so I'll add a note to myself:
Dear Piposquac,
If there are hostiles within a certain range, your character won't pick up any item, even if the enemies are not currently attacking you, and even if you click the items directly.
Just kill every hostile creature in your vicinity and it should work again (btw, that's how you solved it the last three times, you doofus).