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Hey folks. I've beaten two bosses so far (castle + forest), and am currently pulling in 2-6k on a typical run (unless I botch it totally). Here's what I've learned so far:

*Money spending:

----- Return on investment really varies between everything. Some things that can only be upgraded 5x are usually worth it every time you can afford it: potion buff, gold buff. The gate toll upgrade isn't worth getting more than once until super late. Your base stats all need to be pumped together, as they synergize with each other, but individually hit diminishing returns: health, mana, INT, STR, armor, crit chance, crit damage. Weight limit can of course be leveled as needed depending on available gear.

------ Going just melee or just mage with your keep upgrades doesn't seem to work. The way costs escalate, it's a lot cheaper to raise your stats together and use a combined approach that can more easily deal with a variety of circumstances. Both types of damage have enough synergies that they seem to scale well into NG++.

------ After starting over, I've figured out that you don't need to rush to unlock all of the classes. They're more about variety than they are about raw power. Miner in particular is much too weak if you unlock it too early, and Lich similarly doesn't seem to be worth it until late. Shinobi isn't too bad, though, and that pathway eventually unlocks the very important armor bonus; Spellblade unlocks crucial upgrades for Mage users. If you pump health, damage, and enough carrying capacity to wear a full set of Tier 2 gear, then you might want to start thinking about expanding the keep some more - at this point, it's reasonable (but not necessary) to look into Miner and Lich.

------ Runes all cost the same, and get more expensive as you buy more of them. Think carefully before buying a rune you aren't too thrilled about! You probably want an extra jump, a dash, and possibly vampirism. I don't really like the balance runes because it's more flexible to have runes for vamp and siphon separately.

Character building:

It will be a while before you have enough runes/equipment to make any meaningful character building decisions (other than choosing the offspring).

------ Balance health with vampirism. Once you get enough vamp sources, a good balance to me feels like, say, being able to restore your max health in about 10 kills. If you're healing much more than that, then you probably have a dangerously large number of blood items equipped! If you have extra ones, choose which ones to leave out based on which stats are gained and how they'll help that class. You'll probably stop using Blood items altogether around the time you start collecting Tier 3 stuff.

------ Armor is one of the best stats! It synergizes with everything, especially Vampirism and health. Health has good synergy too, since chicken heals 10-15% of your health. (You also need some health upgrades if you want to wear blood items without getting one-shotted)

------ Damage is good too. Sometimes being able to reliably one-shot things dramatically increases your odds of not getting hit in a room.

Boss runs:

------ You'll want to get to the boss and then lock down the castle and teleport in for the boss fight. This way, you won't have to waste slots on vampirism (there is a boss who spams minions, and vampirism is acceptable for that boss, though)

------ Shinobi is nice because you need only play flawlessly for half as long to seal the deal. Knave/Assassin gets amazing free crit damage, so if you can increase your crit chance a bit, they'll probably do more damage than Shinobi in an extended fight. Barbarian King/Queen has a nice special ability, but it's sort of mana hungry and I don't really like it (maybe New Game + is different?)

------ Mages might work for some bosses. Spamming DPS things like Chakram can give you tons of damage per mana, but I haven't tried it yet.

------ Mages benefit from being tiny, while melee classes might have an easier time if they're gigantic. In particular, a Giant standing on the ground can slash away at the first boss while standing on the floor. But if you find it too hard to dodge as a giant, feel free to stick to ordinary size in melee.

Farming:

I don't have this quite worked out to a science yet, but here we go...

------ The safest class for farming out an area is the sturdiest one which can one-shot everything. For earlier areas, this could be barbarian or paladin, while for later areas, this is probably a Shinobi with good stats/equipment. Archmages and/or dwarves can sometimes pick up fairy chests which would be impossible for other characters.

------ I didn't have much trouble killing the second boss soon after the first. After that, the castle and the forest become relatively easy farm, granting 1-8k most runs, depending on setup and whether you mess up and die.

------ If you're doing well in the castle and forest, but not in the tower, consider using Miner and/or Curse to up the challenge/reward of these areas for some more farm. Also try to unlock all the blueprints in these two areas for further power. Sometimes earlier blueprints can drop in later areas, which can be disheartening - if you collect them all, this won't happen anymore.

------ You don't have to kill everything. Usually the gold isn't that great. Often killing things is the safest way to get between places, though.

------ Certain fairy chests can only be gotten by certain types of characters, such as with the right spells/runes or with Dwarfism. Use the architect if one of these really bugs you!

------ Fairy chests aren't really that exciting once you have as many runes as you need, but keep trying to get them anyway. Once you have a complete set, fairy chests start dropping stat buffs instead. (Equal to 1/2 of a manor upgrade in power)

------ The top and bottom areas are SUPER DANGEROUS when you first find them, but try goosenecking just in case. If you're super lucky, you'll stumble into an unguarded chest with a lot of gold or maybe even a game-changing upgrade! At the first sign of danger, run! When jumping up to the tower, try jumping high enough to change screens, but not clear above the floor for a quick coward's glance at the room. Going down into the darkness is a lot more dangerous, as you could just plain fall into a fireball and die.

Gamepads:

I have the Logitech equivalent of an X-box 360 controller. It has made this game significantly easier, though I was able to finish one run with just keyboard. Recent patches supposedly make other types of controllers usable as well.
Post edited July 08, 2013 by mothwentbad
In regards to controllers, I'm using a Wii Classic Controller Pro wired up via GlovePIE and it works perfectly. Might be more affordable if you've already got Bluetooth capabilities on your computer.
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Emong: In regards to controllers, I'm using a Wii Classic Controller Pro wired up via GlovePIE and it works perfectly. Might be more affordable if you've already got Bluetooth capabilities on your computer.
Razer has what is essentially an XBox controller with a 150% price markup. After looking at that first, the XBox controller looks pretty good.
Post edited June 28, 2013 by mothwentbad
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mothwentbad: Gamepads:

I do not own one, but I'm strongly considering it now. You can make it pretty far without the dash rune, in which case the keyboard controls aren't too overwhelming. However, adding dash to the mix (for me) really increases the button confusion screw-ups. :(

I'm considering the XBox controller for Windows after Googling a little and not seeing any strong alternatives.
Yeah, a gamepad is a good idea for this game. I noticed a big improvement in my performance when I switched. Using an Xbox controller myself. I'd recommend it, works well and easy to set up.
Some French guy has already beaten the game a few times (playing a NG +3 so) and is already lvl.350 now (he was lvl.250 a few hours ago). I'm sure there are some strategy hints to get when you see his live playthroughs:
http://www.twitch.tv/nightcrossstreamhd

Runes used: 1xJump, 2xDash, 2xMoney

Interestingly, he didn't upgrade the "entrance tax" past lvl.1until recently so you can clearly see it's not a priority (only useful for "upgrading" your manor) for early/mid level game.
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catpower1980: Some French guy has already beaten the game a few times (playing a NG +3 so) and is already lvl.350 now (he was lvl.250 a few hours ago). I'm sure there are some strategy hints to get when you see his live playthroughs:
http://www.twitch.tv/nightcrossstreamhd

Runes used: 1xJump, 2xDash, 2xMoney

Interestingly, he didn't upgrade the "entrance tax" past lvl.1until recently so you can clearly see it's not a priority (only useful for "upgrading" your manor) for early/mid level game.
Yeah, the entrance fee upgrade is massively sucky. Maybe when everything else costs 100k and you're making 50k per run, you might start cranking this one up, but until then...
I updated the OP some.

* I called the architect a "miner" in places before. Fixed.

* My thoughts on spending gold have developed some. Mainly, the benefits of pumping health/mana/damage/weight limit are quite large, and if you're trying to get through the game fast, you should probably get Tier 2 gear and good stats before you start unlocking classes. The only other thing that really provides big returns on investment early on is armor, and you have to gain Shinobi and the toll upgrade to get that.

It's taking me some time to figure out, but some keep upgrades are definitely more useful early on than others. Sometimes the synergy can be so weak that it's just not worth it at all for a very long time to open up the wrong thing.
I updated the OP. I've found that money is best spent synergizing lots of things rather than just trying to spend as much as possible every time, even if it means everything is expensive and you have 1k left unspent a lot of the time. I've also found that pumping just attack damage or just magic damage kind of isn't worth it because in one case diminishing returns sets in, but in the other case, having an extra strength helps you deal with more situations more easily.