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The screen constantly flickers and the game is unplayable. I have tried disabling visual themes and disabling desktop composition. Morphological Filtering is turned off. I've even tried Alt/Tabbing out and pack in to no avail. These are the only solutions that I have seen posted on this site but none of them are working. The screen is still flickering.

In the game itself everything appears fine except for a constant flicker at the bottom of my screen. However when I click on my inventory the inventory window flickers so fast between existing and disappearing that it is useless. Any window that pops up flickers so fast as to be unreadable. About the only thing I have managed to do is bring up the ESC. window to quit the game.

Specs:

Windows 7 64-bit
AMD FX 8350 processor 4.01 gHz
AMD Radeon HD 7900
16 GB RAM

I've been having a blast with the series so far and was looking forward to finishing it. Any assistance in this matter would be greatly appreciated.
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Same problem here. System specs:

Windows 7 64 bit.

Intel i7-2670QM 2.20Ghz processor

NVIDIA GeForce GT 525M

8 Gb RAM.
This game doesn't play nice with any patching program that hooks into its rendering engine (the video playback method breaks, and since the final boss triggers a FMV cutscene...) so the best advice I can give you if Windows' compatibility settings don't work is to try either sandboxing the game or running it in a virtual machine. Sandboxing isn't likely to fix graphical issues, so a VM might be your best bet, since the VM's own graphics wrapper options wouldn't break FMV playback like trying to softpatch QFG5.exe directly would.

Honestly, I've never had trouble running this game, so I can't really give anything more than generic advice.
I had the same problem in Windows 7 x64 - but it seems the problem is solved by disabling "AntiAliasing - FXAA" option in videocard's settings.