Hi just like the title says, immediately after running QFG5, the game just gives me an error and stops working.
Currently running:

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System Information
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Time of this report: 6/20/2013, 23:49:08
Machine name: D-PC
Operating System: Windows 7 Ultimate 64-bit (6.1, Build 7601) Service Pack 1 (7601.win7sp1_gdr.130318-1533)
Language: English (Regional Setting: English)
System Manufacturer: System manufacturer
System Model: System Product Name
BIOS: BIOS Date: 11/09/12 10:55:34 Ver: 17.08
Processor: Intel(R) Core(TM) i7-3770K CPU @ 3.50GHz (8 CPUs), ~3.5GHz
Memory: 16384MB RAM
Available OS Memory: 16330MB RAM
Page File: 4784MB used, 11543MB available
Windows Dir: C:\Windows
DirectX Version: DirectX 11
DX Setup Parameters: Not found
User DPI Setting: Using System DPI
System DPI Setting: 96 DPI (100 percent)
DWM DPI Scaling: Disabled
DxDiag Version: 6.01.7601.17514 32bit Unicode


Geforce GTX 670 With Nvidia 314.22 drivers

I had the exact same problem. I'm running windows 7 so I'm not 100% sure this will work with other OS.

There is a very quick and easy fix:

Right click on qfg5.exe, go to properties -> Compatibility -> choose windows 95

That fixed everything for me.

Also, make sure you have the latest patches available from sierra help (google it - I found two patches one for version 1.2 and one for xp compatibility. No idea if this helped or not but I did patch the game before figuring out the compatibility trick) also, I updated quicktime to the latest version, seems this is also causing some problems.

Enjoy! I've been waiting for play this game ever since it came out!