I can't even get Quakespasm to launch through Galaxy since updating to Galaxy 2.0 today. I saw that the latest update finally allowed command line arguments, so I thought "Cool, finally" and updated to 2.0. Big mistake.

Managed to fix the game not launching by verifying the game files within the GOG launcher, please see the image attached for location of this option, hope it helps someone with the same issue in 2022