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Just FYI,

I encountered an issue (twice) in which, after freezing and force quitting, the save files were corrupt. Specifically, upon opening Psychonauts, it plays the introductory video, and asks you to pick a bunk.

In this case, it seems to be only the files 'Profile 1-*' and 'Profile 1-*.ini', and possibly one of the 'SavedGame*' files that are affected, and it was sufficient to replace the 'Profile*' files with backup copies. These backups do not need to be recent. I was thus able to load save points that had previously been inaccessible.