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PirateNeilsouth: Loaded the dosbox version as usual but it's not working correctly..
No sound of the display menu that appears in game ( new game e.t.c ) , the options don't highlight when you scroll over them. When you click for example new game a window comes up about a previous save game but clicking close does nothing.

MoO1 or MoO2? Please try to change graphic mode setup. Exemple for first one:
Menu Start // // Master of Orion 1 and 2 // Master of Orion // Graphic mode setup
Also please send us support ticket with this problem and your DxDiag.