When I start the program, It displays an error
In the title bar, "Windows - No Disk"
"Exception Processing mesage: 0xC00013 Parameters 0x000007FEFD9B7240 0x0000000000000004 0x000007FEFD9B7240 0x000007FEFD9B7240
I installed it to C:\DosGames\Jack Orlando, since I've had some issue with older games, and Vista's file protection enforcement under Program Files.
The install went flawlessly, no errors or other problems were evident
If I click the "Try Again" button, it seems to continue. Haven't gotten anything accomplished yet, though I noticed the music seems to be drowning out the speech.
Pentium i7, 940 2.99 Ghz
6GB ram
NVidia 280 1024
700Gb HD
Soundblaster X-FI

I have the same problem with WinXP 64. The intergrity check passed 100%.
If I hit continue four times, then the game starts, but it's really annoying. The dialogue lags a bit behind the actual movement of lips, but I'm not sure if its just the game or something else.