I think we're having the same issue.
Was playing Tian Shan River, got nearly to the end. I've kept one save file for each level that I save over periodically.
All was working fine, I reloaded the save file for that level after making a mistake, and suddenly nothing is working. I can usually call up and navigate the inventory, though once, even that wasn't working.
If I load an old save state, all is fine. But nothing responds on this one save state.