It's very playable on mouse/keyboard (after a time of adaptation of course, i'm still dreading all those platforms on the outdoor frozen arcology underside section when i tried to go for the aegis armor), i managed to complete the game once.
Lots and lots of dying though :D as i'm nowhere near great at this whole thing, but the atmosphere of the game and the design was so good that i kept trying again and again while grinding more points until i finally got to the ending toward a NG+
I don't have the DLC, but Hellpoint is really worth playing.