Bumping this thread because I'm having a similar problem.
When I start a new game, I can hear the voiceover and see captions, but the intro video isn't visible. When I move between areas, only a sliver on the bottom of the screen is updated, with the rest of the screen either being black or displaying an image of the previous area. The same thing happens when I switch between the characters. Bringing up the help menu and closing it sometimes allows me to see things again (but only until I transition to a new screen), although sometimes it has no effect and sometimes it only displays the half of the screen.
I've tried various compatibility modes to no avail. Running the game with 256 colors alleviates this problem, but it messes up some of the game's colors (most noticeable in the main menu and bar containing the help, save, load, etc. options that appears when you move your mouse to the top of the screen). It also results in some graphical anomalies.
I'm playing the CD version on a laptop with Windows 7 Home Premium, an Intel i5-2430M CPU @2.40 GHz, 6 GB RAM, and an NVIDIA GeForce GT 520M updated to driver version 301.42 (the latest version).
Post edited June 14, 2012 by junovalkyrie