ShogunDarius: say i download game 'X' play it and make several saves, then gog make a new version of the game to download and i download it and install it to the same place, what would happen to the game saves?
I can't image GOG's game modifications affecting save games. Only exeption would be games that needed unofficial patches to work but those are pretty rare. Nor are GOG modifications usually big enough to warrant switching over mid game if your installed game is working well. I'd suggest finshing ongoing game before switching unless GOG reports that they fixed something game breaking.
If you still want to switch mid game, I'd suggest backing up the save games (also obviously uninstall before you install the new version as GOG does not provide patches so you can't really upgrade previous installation. Installing over existing game may wreak havoc on your registry.). I havent' uninstalled enough GOG games to know wether or not they allow preserving save games.