Mass Effect 1 had the star map disabled if it detected a cracked copy (that one got me to buy the game).
Beyond Good and Evil uninstalls the game just as the install has finished if the driver won't install (that one got me to buy the GOG version when I already had the game on disc).
Stardock's Windowblinds made the desktop black and gave the skins other oddities or disabled parts of them (this, and a reply on to another user on the support forum about it got me to buy the software 8 years ago or so).
... see, DRM works (hush, don't tell them).
serpantino: I know some of the older games actually had a physical device (decryption I think) that you had to plug into a parallel/serial port to get the game to run. That was some strange and OTT copy protection.
There are more recent examples with USB sticks, probably not for games, but other software.