This both makes me laugh and cry.
http://www.eurogamer.net/articles/2013-04-29-game-dev-tycoon-forces-those-who-pirate-the-game-to-unwittingly-fail-from-piracy

A game about game developing, where, in the pirated version, your company goes banktrupt because of piracy, and some of those playing it don't see the message.

I just saw it already goes on in another thread- go there
http://www.gog.com/forum/general/game_dev_tycoon_antipiracy_in_a_game_development_simulator/page1