Epsilon: using the correct version of Wine for the various games.
astropup: I think this is a prejudice. I've never had much success with what people called "the correct version". The latest version usually works just fine. Ok, there is a possibility of regressions, but that nowadays happens rarely. But, usually, it's more of a placebo. And regressions get fixed soon.
Theres always regressions version to version, and sometimes bugs are not fixed to the version after that.
As an example here's the latest wine devlog
http://www.winehq.org/wwn/372 While theres certainly a lot of improvement going on, there are multiple titles on that list that simply stopped working for this new version.
And thats not a unique occurance, it's always going to be like this with a piece of software as complex as wine.