The Fright and Mix packs are currently the best sellers of the packs. I haven't played any of the Fright games (but picked it up) and I already have all the games but Plain Sight in the Mix pack.
First pack I picked up was the 2D Pack. I already had VVVVVV but was interested in the other games (and had wanted Geometry Wars for some time). If you don't already have VVVVVV, it's a great game. The pack is the normal price of the game, and VVVVVV has no DRM.
The Future pack has some cool looking games. Flight pack, not so much, but it looked interesting. The Kids pack isn't too hot, I've passed on that one, but Toki Tori is a great puzzle game that's already on sale right now. I got it when it showed up on Steam since I loved the Gameboy Color game.
Personally, I love the 2D Pack, but the Fright pack is a best seller, so there's probably a good reason behind that.
Don't forget to check out some of the less obvious sales. Grotesque Tactics is the last daily indie deal. Toki Tori, P.B. Winterbottom, CivCity: Rome, Shattered Union, Magnetis, Caster, Ghost Master, Blueberry Garden, Gumboy Tournament, Gravitron 2, SlamIt Pinball Big Score, Evil Genius, Sniper Elite, Windosill, the X-Com games, Freedom Force, Puzzler World, Puzzle Kingdoms, Sid Meier's Pirates!, RUSH, Eversion, Obulis, Ziro, Everyday Genius: SquareLogic, and plenty more are all $2.50 or less.
Some of the games I listed, I don't personally think look so good. I've personally picked up P.B. Winterbottom (I'd been wanting the game since it showed up, and for $0.50 I couldn't pass it up!), Magnetis, Gravitron 2, Puzzle Kingdoms (it was a daily deal), and Everyday Genius: SquareLogic.
Shattered Union, I don't even know if that's worth $0.50. Any opinions? Again, Toki Tori is awesome. I've yet to play RUSH, I even picked it up the first day when I got a Toki Tori group alert and it was $4.50, but it's from the creators of Toki Tori and looks like a good puzzle game. Not sure how Magnetis is, but it looked interesting and it's $0.50. Eversion I've passed on. The original (free) game was pretty cool, but very brief. Check it out if you like supporting developers and 'enhanced' graphics.
Just look into some of them first. SlamIt Pinball, for instance, has some serious issues going on between the developer and the publisher, Strategy First, with plenty of people on the forum to explain why you should probably pass on it. Your call, though.
Check out
this site to see all the sales in one place, read some comments, organize by saving percentage and price, and what have you. I normally use the RSS feed at a glance the rest of the time to quickly see what's on sale. However, the list is absolutely huge right now, so just check out the main site. The RSS feed can be very useful later, of course...