With the whole recent discussion of a seizure-inducing light sequence in an upcoming game, I feel like it's worth having a discussion about other elements in games that are painful to use.

For example, in my case, the sound of an electric guitar has been known to cause me headaches, to the point where it's painful to play games whose soundtrack makes heavy use of that instrument. Also, watching Daggerfall videos can make me a bit nauseous (isn't as bad when I'm the one playing, because I don't use mouselook and I'm the one in control), and Crimzon Clover isn't really a game I can watch or play for long periods of time because of all the visual noise.

So, what other games are painful for you to play, to the point where you need to be careful of how much you play them, or you need to make configuration changes or install mods to try and minimize the issue?

Depends on what you mean by "pain". Eg, badly done head-bobbing, extremely narrow FOV's or excessive camera shake regularly increase motion sickness for many people. Personally I don't suffer from motion sickness, but I always turn off head-bob simply due to how ridiculous it looks.

Hyperdimension Neptunia voice overs. Honestly, they cause me a fit of apoplexy so that I can't play an otherwise enjoyable game.

Chromatic Abberation also causes me to get headaches if it lasts for extended period in games. As a flash, its not so bad (initial discovery of meditation points in Jedi: Fallen Order for instance) but games that keep it up as part of the aesthetic cause me some pretty severe discomfort.

YOU AGAIN?
Listen listen listen. It's not very difficult.
This is a video game. A video gameeeeeeeeeeeeeeeeeeeeeeeeeeeeee. It's not a physical torture device. It's a software you can turn off, usually designed to please you. Physical torture devices cause pain. The most pain I've experienced from any piece of audio or visual media is from ear rape tracks on youtube, which are honestly funny.

PS: "The whole recent discussion" Is a bit of lofty language considering THERE'S LIKE TWO PEOPLE WHO AGREE WITH YOU and YOU KEPT IT GOING LOL

I see what you are doing. You are trying to create an impression that there is an issue. There is no issue. You are only doing this to hurt CDPR and potentially other companies who don't side with you when it comes to this non-issue. Keep your politics to yourself, person. It's very obvious what they are doing, by how they say "With this whole discussion of seizures" which is a discussion only they and maybe 1 other person created - I do not recommend you engage with them. Report them for violation of forum rules, these posts belong under CyberPunk sub-topic. All they are doing is trying to make it seem like an issue exists, the existence of which they can then use for their own purposes. And all they are also doing is spamming the holy hell out of Gen Forums with this thread and another thread on the "CyberPunk is a CIA torture device that is designed to cause seizures" fake news drivel.

Not really pain, but the first Prey (2006) gave me severe motion sickness. Which is weird, since it doesn't bother me at all in AvP playing as the alien, where I think motion sickness usually kicks in for people susceptible to it.

I don't easily get motion-sickness or sea-sickness. I used to play games in a tiny window when my system's specs weren't up to running it on my native res. I'm pretty resistant to visual discomfort in general, so I don't have any examples aside from Bloom being an abomination that gets turned off immediately.

I have noticed RPGM games blast my years, like seriously why are they so loud by default? I have to bring it down to 15% or so to play them comfortably, and that's just not an issue I have with most games.

I have a problem with:
shake effects of the whole screen. Why should I experience an earthquake from a 3rd person point of view as the screen moving quickly in every direction? Represent an heartquake decently or leave it.
white screens, expecially when I'm playing in the dark - hate them, had one in Count Lucanor recently as a cheap way to show that the protagonist is waking up
too much rumble in the gamepad, or not being able to turn it off - that might end up giving me actual discomfort to wrists and forearms
annyoing audio samples in the backgroud going on and on, like a character snoring with the same repetitive sound, or the hammering in front of a blacksmith's workshop - in many point and click adventure's screens - I might to have to turn the audio off in those screens
tearing for lack of vsync - I'd rather low the fps than have tearing
I don't think I suffer from motion sickness in a particular way, I can't think of a game that gave me that, even when others were complaing about it. I think I have more problems with noises then anything else and a sound that's not properly produced and it's loud and metallic might force me to keep the fxs very low. And this is the only thing I could define painful as it may hurt my ears - apart from the gamepad rumble that's somewhat external from the game per se.

Too many colourful lights confuse me and make the scene hard to understand, for example those used to represent magic energy in fights in many games.
Often in movies when the camera is quikly moving along the scenery (I can't think of a proper word for this kind of shot now), I have to look away from the screen because the framerate is too low and it's not smooth enough (24 fps is not decent for this in my opinion). It might happen in games too and there's usually nothing I can do.

I stopped playing System Shock: Enhanced edition, because the free floating around in Cyberspace made me feel queasy and I was afraid of vomiting over my laptop.
Might try it again some time, but really wasn't a fan of that disorienting cyberspace experience.

There are some effects in the early Pokemon games which are best not listened to. Such as Screech (VOLUME WARNING) or Thunderbolt in Gen 1.

The visual effect for Thunderbolt is especially obnoxious.

Of course, the opposite problem now exists where the pokemon barely animate and the attack effects are lazy as all hell.