(Might and Magic 5 puzzle spoiler)
Something that's not quite as significant, but still should have been caught in testing: One particular puzzle in Might and Magic 5.
There is one point in the game where you encounter some puzzles from the Vowelless Knights; you are given the consonants from one saying, and you have to type in the vowels as your answer. Well, there is one saying where they made a spelling mistake:
"If wishes were horses, beggers [sic] would ride"
So, you get to this puzzle, you see just the consonants, and think of this saying. You then, knowing that the word is spelt "beggars", type in the answer with an a. Unfortunately, because the game's developers misspelled the word (and you had no way of knowing), what should be the correct answer is marked as incorrect.
Fortunately, the puzzle can still be solved, because the answer the game considers correct is given to you elsewhere, and you later get to see the entire saying (*with* the misspelling), but one of the testers should have noticed this mistake, especially since you do get to see the entire saying.
(By the way, this sort of mistake can come up in tests in school; if the answer key is wrong, students will unfairly lose points as a result, at least until somebody notices the mistake.)