dnovraD: The way GOG implemented these mods as I understand it, is wearing their hat on their bottom and their trousers on the head. Instead of a little patch (or not so little if it's a total conversion), you get the whole game with the mod preapplied.
So that will definitely change how other mod installers detect the game, and will be worse than redundant and/or useless for games like Starbound and Civ IV, where their entire engines are modular.
Or games like RCT2? OpenRCT2 has a content manager and new/improved content, plus the mods would be absurdly numerous and tiny!
Plus I can imagine some modders specifically coding exceptions for the GOG version because of past mistakes GOG has made.
I'm of the firm belief this whole thing will be a painful lesson for GOG.
Let people mod games the way they want, and do not get involved.
Say you have a modder who has been making mods for decades. Now, add to this the thousands of modders who have used this modder's work in their mods. You are leaping into a minefield of conflicts, duplications and complaints, not to mention any legal repercussions that arise later.