clarry: It kinda does matter; for example, you almost definitely want a distro that uses glibc, and you want a distro that packages 32-bit libraries. Generally speaking I also recommend you avoid so-called "stable" distros (like Debian or RHEL/Rocky) with a long support cycle and outdated packages.. not that they necessarily won't work, but if you happen to need some more recent packages (e.g. for new games or new hardware), then it can be a massive ducking pain. There are also differences in support for non-free drivers (NVidia) or non-free packages.
glibc.
Got it. Okay, thanks. re:NVidia. I have actually been burned by AMD before, but regarding Linux support I heard AMD is better -- so I'll stick with AMD.
clarry: If you need to ask, then I recommend you stick to something relatively mainstream, but it's hard for me to endorse any particular distro. That said, Fedora has served me well at home and work for the past few years. I know a lot of people would recommend something like Ubuntu or Mint, but at least the former has burned me too many times...
I have actually Mint installed on an older laptop. It works fine, but I don't use it for gaming.
EverNightX: You are correct that any distro *can* work. It's just that installing software on Linux is easiest if you use the distro's package manager. And some distro's have package libraries that are not updated frequently and thus may not have recent versions of WINE or graphics drivers that you might want for newer games.
Yes. That's why I'll aim for some distro aimed at gaming from the get-go; like SteamOS.
EverNightX: One option that can work pretty safely for most any distro is to not use Galaxy but instead install Steam,
then Steam > Settings > Steam Play and toggle the option “Enable Steam Play"
Then add your GOG games to it as non-Steam games.
Considering the original title of this thread is/was ''Galaxy works fine with Wine'' this part is very ironic! ;D
Appreciate it. =]