nightcraw1er.488: Really, where exactly is the source for this information that Beths games don't like Win10?
I just wrote that as a simple explanation.
I dualboot 10 and 7 but stick to 7 (for games that is, I use Linux as my main), and I'm basing it on the fact that many of those with problems with Bethesdas games also use win10. These games haven't been touched by Bethesda in a long time so it's only natural they work relatively poorly on win10 (an os that is known to work poorly with many older games
without workarounds). There can be many causes to these issues, but it's faster to just go through a list.
So yes, installing to other folders than a sys folder, quit using Galaxy, installing unofficial patches, and checking geforce experience/Radeon software or anti-vir software if there is something there, have helped some.
I've personally experienced only 2 (as far as I remember) reasons to why F3 crashes on my build; some background process that used about 100%, and due to mod.
EDIT: come to think of it, one time some files got corrupted (on a older build) but haven't seen any kind of that lately, so yes, in some cases corruption in memory, CPU, mamaboard or hdd can cause problems. Corruption in memory or data in transit happens far often than most people realize.