HandmadeComa: I'm having problems with this currently as well, using 3 different browsers all doing the same thing.
I click Wishlist and it turns that orange color for a split second then reverts back to the black "Wishlist it" and if you click it a bunch of times it will eventually save but nothing is added to my actual wishlist.
Edit: Just tried to remove some games from my wishlist and apparently thats broken as well for me. Not sure what I can do here.
Still no problems in that regard on my side.
Can add and remove games from my wishlist just fine.
HandmadeComa: I am at 75 games so maybe thats a limit?
Nope.
To not make some outdated statement, I tried crossing that number successfully just now, and still could add and remove games without fail.
Apart from that: there are users here on GOG with several hundreds of games on their WLs.