I can't load my Save Game in Windows 10 x64.

Could be any number of things, different version of the game for instance, corrupt file. Have you tried playing it, saving, and then loading that? Have you installed the game Outside Windows folders - very important - always install any application outside Windows folders (i.e. create c:\games or something like and install there, this avoids all the Windows UAC issues). Finally the gamecard for the Blood 2 game does not show compatability with Windows 10, you could try Support, but if its not a supported OS...

Yeah, That's a problem. I hate when games work fine on my old system when I bought the game, but not when I update. I understand it's an inevitable problem, but still rankles me when I can't play something I bought.

Indeed. I can't really imagine its a Win10 specific thing though, unless he doesn't have DirectPlay enabled or has installed to Windows folders and UAC is preventing something writing.

Might be helpful if the poster mentions what happens when he or she tried to load the saves.