Currently on Linux Mint 21.3 XFCE edition. Can NOT for the life of me get mods to work in-game at all with the GOG version of Fallout 4. I've tried literally everything, Vortex, MO2, Wyre Bash, the works. I even attempted adding the game to Steam to no avail, and when the mods do work, the screen is windowed, and the sound is muted. Can anyone please help?

What kind of dependencies do your mods have? I mean, are they steam mods?

No, they're mods downloaded from the Nexus.