You can go to game menu and if you turn on fullscreen, then go to options, set the mouse view controls, and rebind the keys, like movements ones to WSAD, use to E, etc., you can get modern controls in this game easily.
Only thing which you can't change is holding right mouse button and swinging with it in order to attack with your weapon and then I think the F1-F4 keys for changing the interaction mode.
And also remember, that during combat each time you hit enemy you should moving back and forth to try to dodge his attacks. The best is to time this with your attack, depending on your attack speed.
And also, in the beginning you aren't supposed to kill all enemies. So if you find some enemy which you can't kill for some reason (like instakilling you or just not having right weapon type), you should run.
And also this is not about controls, but more about mechanic, but in this game, if you want (and you should have) level up your character, you won't get any experience. Instead, you have to raise your primary, major and minor skills, so choose your class well or create your own depending on which skills you want to use.
And last one, don't be afraid to use the main quest guide on uesp website, as there are (if you are using community fixes, if not, then it's broken)level limits for the quests.
Post edited January 31, 2019 by Reginald_CZ