I am trying to get Duke Nukem Atomic edition to play. I have tried clicking setup, the shortcut icon and going into program files and clicking everything there. I am running vista and have plenty of hard drive space and memory as far as I know. I don't know what to do as I am not computer friendly
Firstly, this thread was resolved and closed so you really ought to start a new thread rather than re-open this one.
Secondly, you've not given anywhere near enough information for anyone to be able to help you. What version of Vista are you using? Is it 32-bit or 64-bit? What are the specs of your machine? CPU? RAM? GPU? Are you running the app as an administrator? Have you tried various compatibility modes? Also, why won't it run? Any error messages? Crashes? What happens, if anything?
Additionally, I recommend not using the Program Files folder as it is a protected folder and can cause issues with older software.
You might also want to use eDuke32 instead of the bundled DOSBox that GOG provides.
Also, have you raised a ticket with GOG support?