When I'm using a controller with Xpadder, it almost always crashes on the first level at the pile of toxic drums where the blue item boxes. When I'm not using a controller. When I'm not using a controller, it crashes on the first level when I reach the location in the enclosed image. I have also enclosed the image of the pile of drums in case anyone didn't know what I was talking about. I've tried running the game in as administrator and in various compatibility modes, none of which seem to change anything for the better.

Try changing the output mode (via Graphics mode setup) to OpenGL.

Okay, I'll give that a try. For the record, it's on Overlay before I switch.
UPDATE: Okay, it's better. The screen still went sideways a couple of times for some reason (DOSBOX probably has some compatibility issues with rotatable tablet displays) but it's a start. I think I'll try some of the other settings, but thank you for the tip.