There are plenty of reviews here which are helpful however they all miss one important piece of information.
Playing this game in DOSBOX on a new HD screen is a dreadfull experience. Thankfully 3D Realms released the source code for Duke long ago under a GPL (or something similar) License and a few awesome Fans made a High Resolution Pack to the original game (bringing the graphics up to something similar to the Duke Nukem 64 release). The HR Pack does not change the game or add functonality in any way it just upgrades your graphics textures,models e.t.c. If you want to check it out go to http://hrp.duke4.net/
Naturally this is just a modification of the original game so you need to buy the game download and install it then apply HRP :D