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I am in lothering at the moment and have been enjoying the game quite alot. I had trouble with launching it would just endlessly try to load Then if I could get in it would crash after a minute this is happening I have no idea how to fix it.
Is it after a minute or when you moved to a specific location inside lothering? it might happen because you come in sight of an event or people, and there is something wrong there.
Try patching your exe with the 4gb patcher, it worked for me.