title says it all, I know Denerim is very prone to crashing because there's so much going on there, but I literally cannot even open a chest without the game crashing there. It's at the point where even opening the save is crashing the game. I've verified my cache at least 3 times now and I'm now currently debating reinstalling it.
I've done most of the other quests but having to scrap a 20 hour playthrough is pretty disheartening, is there any way to fix this?

Have you tried any of the tips found in this thread - http://www.gog.com/forum/dragon_age_origins_ultimate_edition/denerim_crashes_workaround - if not, hopefully it'll help.

Wasn't able to pull this up when I searched for Denerim Crashes, but turning it to Medium graphics fixed it apparently. thank you!

Glad you've found a solution :)

Today I visited Denerim first time, save and leave game. But when come back saved game crashed every time. Thank you Pajama for help! 4gb patch helped me now everything work again :)