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I successfully installed DA:O, opened it up and checked that the DLC were all there, closed the game and tried to run the patch, but it won't run. It gives me an error message:

Unable to execute file in the temporary directory. Setup aborted.
Error 5: Access is denied.

Tried to run it from the same directory as DA, no change. Can't figure out what temp file I'm missing, if any. Is a reinstall called for?
This question / problem has been solved by Gydionimage
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iamadesertcreature: Unable to execute file in the temporary directory. Setup aborted.
Error 5: Access is denied.
This is typically AV/Security software interfering with the install (patch in this instance). Try temporarily disabling it.
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iamadesertcreature: Unable to execute file in the temporary directory. Setup aborted.
Error 5: Access is denied.
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Gydion: This is typically AV/Security software interfering with the install (patch in this instance). Try temporarily disabling it.
It's been so long since my security progs dared to interfere with my machinations, it didn't even occur to me! Working fine now, many thanks to ye.