I've tried over 50 games on my splendid new Apple Silicon Mac mini and DOS:EE is one of only three games on Gog that has not worked. It crashes immediately (after doing the Rosetta translation) with a very verbose log.

I've tried launching from Galaxy, and running the app directly with 'Open in Low Resolution' selected, and tried changing the settings in the menu that appears when you hold down the Command key, but no joy.

It's a 64bit app that works fine on my old Intel-based Mac mini (plugged into an eGPU) under Catalina.

Heres the first part of the log...

--------------------------------
Process: Divinity - Original Sin [4397]
Path: /Applications/Games/Divinity Original Sin Enhanced Edition.app/Contents/MacOS/./Divinity - Original Sin
Identifier: com.larian.dosee
Version: 2.0.119.208 (2.0.119.430)
Code Type: X86-64 (Translated)
Parent Process: ??? [4389]
User ID: 501

Date/Time: 2020-11-18 16:12:24.034 +0000
OS Version: macOS 11.0.1 (20B29)
Report Version: 12
Anonymous UUID: B56203BD-54D6-0587-E9F4-4846D011833B
Sleep/Wake UUID: 30DE5A1B-75D0-4D8C-AE3C-4C00D8512E81

Time Awake Since Boot: 18000 seconds
Time Since Wake: 7500 seconds

System Integrity Protection: enabled

Crashed Thread: 0 Dispatch queue: com.apple.main-thread

Exception Type: EXC_BAD_INSTRUCTION (SIGILL)
Exception Codes: 0x0000000000000001, 0x0000000000000000
Exception Note: EXC_CORPSE_NOTIFY

Termination Signal: Illegal instruction: 4
Termination Reason: Namespace SIGNAL, Code 0x4
Terminating Process: exc handler [4397]