Have you tried other DirectX 11 games? This could be a hardware issue (in which case other, similarly demanding games should also be affected), or a driver problem.

Check for updated graphics drivers and Windows updates in general.

If you check the Event Viewer, does that give an error code or 'Faulting Module' file name that might help identify the cause of the crash?
- click Start (or WinKey-R), then type "event viewer" into the search box. in Windows 10, 'event' should bring up 'View event logs'.
- after starting the Event Viewer, expand 'Windows Logs' in the left column and select 'Application'
- in the center column, look for a recent error (maybe sort by Date and Time) for the game
- check the information under the 'General' tab below the list of events, starting with "Faulting application name..."

Especially if the faulting module name is something graphics related, you can try a clean re-install of the graphics drivers. See or [url=http://www.tweakguides.com/NVFORCE_3.html]here, for example.
Before that you could try just resetting your graphics driver's 3D settings to default (right click an open area of the desktop to start the nvidia Control Panel or ATI Catalyst Control Center).


Are you shutting down all non-essential programs (especially anti-virus) before starting the game? Firewalls can cause conflicts (generally on startup or loading screens, though) and overlays from graphics tweaking/monitoring programs or chat programs can also caused issues.

Have you tried lowering the graphics settings and resolution, or switching to Windowed or Fake Fullscreen display mode, to see if that would make a difference?

Try disabling texture streaming (that is the main cause of reloading textures). This may also improve performance, but increases memory usage, so could cause stability issues on systems with only 4GB RAM. With D:OS EE, at least, this could cause a crash on startup (FWIW D:OS 2 started fine on my system when I tested this), but it is easy to change back if it does.
Open the graphicSettings.lsx configuration file (in the '..\Documents\Larian Studios\Divinity Original Sin 2' folder) in Wordpad, or other text editor, and search for the term 'Stream'; two lines below that, change the one to a zero and save to disable texture streaming.

<node id="ConfigEntry">
<attribute id="MapKey" value="TextureStreamingEnabled" type="22" />
<attribute id="Type" value="0" type="5" />
<attribute id="Value" value="1" type="4" />
</node>


In the bin subfolder of the install folder, start the game from the SupportTool.exe rather than EoCApp.exe, and if/when the game crashes it can upload a CrashDump file for the programmers to take a look at, as well as a text description you can add.