Has anyone else seen this issue? I'm wondering if it's because I'm using a 32:9 ratio ultrawide monitor.

See the attachments for an example of what I'm talking about.

yes, everthing hud like coming to the edge of the screen does this. npc markers, too.
but lightslogo on shops are no problem.

Yeah, it's even worse when I play in triple-monitor setup, 48:9 (7680x1440). The edges are so blurry it's barely readable.
However, this issue seemed to be just in the beginning on the game for me (started playing Phantom Liberty on an existing save), right after Songbird gave Johnny the boot during the intro mission.

It's currently fine for me, but I have also played around with the new system settings, and disabled all of them, so there could be a simple ingame graphics fix for this.

EDIT:
I didn't notice this was a major necro of the thread...

I only experienced this on the current 2.0 PL patch when DLSS was enabled. Which DLSS I used (quality, balanced, etc.) did not seem to affect it at all, it seemed to be just as bad regardless of selection. Updating the DLSS dll to the newest 3.5 version also did nothing to prevent it.

I simply disabled DLSS (and took the performance hit, ouch) because it hurt my eyes after playing for a little bit.

Hope this helps!