BloodRayne 2 is a good game, but it can be difficult to play with the keyboard and mouse. This is especially the case when you use the default settings. You can either use a controller or just change the keys. Let's do the latter. So here is an overview of my settings i use in BloodRayne 2. Offcourse, you can always use those keys which suits you the best.
Anyway, here's the list:

Keyboard settings
Forward: W
Backward S
Left: A
Right: D
Bite/Harpoon: E
Target Lock Mouse thumb button
Jump: Spacebar
Blade Attack: Mouse Left button
Kick: Mouse Right Button
Fire Weapon: Ctrl (control) / F
Blood Rage: 1
Aura Vision: 2
Dilated Perception: 3
Powers Off: 4
Cycle weapons: mousewheel
Cycle Lock-on Target: Alt
Circle combo: C
Walk: Left shift

Controls
Auto Lock on attacker: off

Camera
Vertical Control: Reversed
Horizontal Control: Normal
Vertical Autocenter: No

I use myself a Logitech G15 v1 keyboard and a Logitech MX518.
The MX518 does have 2 thumb buttons. I've set for the target lock on the upper thumb button. Setting blade to the left and blade to the right has the advantage you have quick access to them. For fire you can use control, but also can use the F button. Those ones are easy to reach. Now i often use the F button myself.
With the camera i first had to have the view quickly go from up to down, which can be annoying and can cause some rsi. So with setting the vertical control to reversed you don't have that anymore.
With changing some keys in Bloodrayne 2 the game becomes more playable.