I can confirm that on macOS the config file is named 'configfile' and this works for me.
Here is what I have in my log file after starting Blade Runner:
[2020-01-13 19:42:58] ScummVM 2.1.0 (Oct 12 2019 14:39:59)
[2020-01-13 19:42:58] Vorbis FLAC MP3 SEQ TiMidity RGB zLib MPEG2 FluidSynth Theora AAC A/52 FreeType2 JPEG PNG cloud (servers, local)
[2020-01-13 19:42:58] --- Log opened.
[2020-01-13 19:42:58] Using configuration file: configfile
[2020-01-13 19:43:17] WARNING: No path was provided. Assuming the data files are in the current directory!
[2020-01-13 19:43:17] Using pixel format: ARGB8888@4
[2020-01-13 19:43:18] Download SUBTITLES.MIX from ScummVM's website to enable subtitles
[2020-01-13 19:43:18] WARNING: numQueuedStreams: 0!
[2020-01-13 19:43:21] WARNING: numQueuedStreams: 0!
[2020-01-13 19:43:22] WARNING: numQueuedStreams: 0!
[2020-01-13 19:43:24] WARNING: numQueuedStreams: 0!
[2020-01-13 19:43:26] Blade Runner
[2020-01-13 19:43:26] From the dark recesses of David Leary's imagination comes a game unlike any
[2020-01-13 19:43:26] other. Blade Runner immerses you in the underbelly of future Los Angeles. Right
[2020-01-13 19:43:26] from the start, the story pulls you in with graphic descriptions of a
[2020-01-13 19:43:26] grandmother doing the shimmy in her underwear, child molestation, brutal
[2020-01-13 19:43:26] cold-blooded slaying of innocent animals, vomiting on desks, staring at a
[2020-01-13 19:43:26] woman's ass, the list goes on. And when the game starts, the real fun begins -
[2020-01-13 19:43:26] shoot down-on-their-luck homeless people and toss them into a dumpster. Watch
[2020-01-13 19:43:26] with sadistic glee as a dog gets blown into chunky, bloody, bits by an
[2020-01-13 19:43:26] explosive, and even murder a shy little girl who loves you. If you think David
[2020-01-13 19:43:26] Leary is sick, and you like sick, this is THE game for you.
[2020-01-13 19:43:26] JW: Don't forget the wasting of helpless mutated cripples in the underground.
[2020-01-13 19:43:26] It's such a beautiful thing!
[2020-01-13 19:43:26] DL: Go ahead. Just keep beating that snarling pit bull...ignore the foam
[2020-01-13 19:43:26] around his jaws. There's room on the top shelf of my fridge for at least one
[2020-01-13 19:43:26] more head... - Psychotic Dave
[2020-01-13 19:43:38] MG: Is David Leary a self-respecting human or is he powered by rechargeable
[2020-01-13 19:43:38] batteries?
[2020-01-13 19:44:06] --- Log closed successfully.
You could try to start the application from the Terminal to see if that gives more information on what goes wrong. To do so:
1. Open the Terminal application
2. Drag & Drop Blade Runner.app on the Terminal window.
3. Erase the space at the end and add '/Contents/MacOS/GOGLauncher'. For example if Blade Runner.app is in your Applications directory you should now have /Applications/Blade\ Runner.app/Contents/MacOS/GOGLauncher in your Terminal window.
4. Press Enter (or Return). This will execute this command and should start the game.
5. After it crashes check the information that was printed in your Terminal window.
It just tries to open it but it but then it turns all black my screen and the pop up saying it shutdown unexpectedly appers. And this down under is what it says in the terminal:
2020-01-13 21:35:16.400 scummvm[1746:175086] NSDocumentController Info.plist warning: The values of CFBundleTypeRole entries must be 'Editor', 'Viewer', 'None', or 'Shell'.
Assertion failed: (p < _size), function setChar, file common/str.cpp, line 464.