HI this issue it seems is still unresolved?
Running Mac OSX High Sierra 10.13.5
I had the same problem with ALL the Blackwell games, but somehow got each of the others to run using your suggested workaround (disable autodetect in Wineskin).
However no such luck with Blackwell Epiphany - which I paid full price for I might add.
Will I be able to play this game or do I need to request a refund?
So I bought and downloaded Blackwell Epiphany for Mac on the GOG Galaxy app, and when I go to press play the app just crashes right away. It doesn't open at all. Any suggestions?
Do you run the latest version of macOS?
Unfortunately, there is a problem with macOS 10.13 High Sierra - games using Wineskin, such as Blackwell series might have stopped working with this update. We are working on addressing the issue but there is no ETA when this work will be done.
In meanwhile, here's a workaround that you might try: http://wineskin.urgesoftware.com/tiki-view_blog_post.php?postId=87
If that won't help, please write to our support: https://support.gog.com