Sorry if I'm dabbling in necromancy here, but I have some information that is relevant.
I'm not certain of how much use this is (I set it up in a PlayOnLinux Wine prefix, but have since deleted it and can't remember the settings), but six months ago or so, I was able to play it fine. The prominent issue that I remember was that the player's avatar was a bit buggy (no pun intended; a lot of white artifacts). The game ran smoothly, from what I remember. I watched the prophet(?) roach's cutscene, got past the spider at the very beginning, and then things happened and gaming fell from my priorities for quite a while.
I guess my point is: it does work in Wine with some tweaking--or at least it did at some point fairly recently. If anybody is still interested in this, I can try to recreate the POL prefix I'd set up.