So far the game has been running very smoothly with no issues at all.
However, once I walk into the Sender Station common area, the frame rate drops all the way down from 60 to around 10.

Has anyone else encountered this and if so, is there a known fix for it?

Edit:
Here are my specs

OS: Win 10 64-bit
RAM: 32GB
GPU: Nvidia 1080FE
CPU: i7-5820K
Display: 2560-1440P

I have this problem a well on my GTX 1050 (2GB), but on worse, integrated AMD Radeon HD 4250, the problem doesn't exist.

Just reached Sender Station and encountered the same problem, NVIDIA GTX 750, windows 7. Still looking for solution.

EDIT: setting compatibility to Windows 98/ME fixed it for me.

Just put "Threaded Optimization" to Off in the game's NVIDIA driver profile. That solved it for me.

oh my.