THE GAME: "Destroy All Humans!" is an affectionate parody of classic black & white sci fi cinema. Unlike in most of those movies, though, the protagonist is the alien. Like in most games in which you play as a villain, the focus is on fun. Scare, fool, control, fight and destroy all humans in your path both on foot or your flying saucer, with an increasing variety of abilities and weapons at your disposal. Unlock all kinds of extra content (the original included even a full movie, "Teenagers from Outer Space", as an unlockable).
THE REMAKE: Unlike, say, the Resident Evil 2 remake that takes the elements of the original and reimagines them in a different way, this one is a full 1 on 1 remake with the same gameplay and even retaining the same voice acting from the original. Rather than simply remastering the game by upscaling the resolution they remade the graphics from the ground up, in order to keep the experience of the original more or less intact and letting more gamers be able to play this classic.
The game looks great. Fortunately they kept a similar art style rather than going for photorealism. Everything else has been kept more or less the same, but streamlined. The UI is more friendly, particularly in menus. A few bits of the gameplay have been refined to be less frustrating. Overall, this is the optimal "Destroy All Humans!" experience.
The game runs pretty well, even in my middle-ground PC. I can't speak for keyboard and mouse controls, but with a gamepad the game controls fantastically. It was designed for a gamepad in the first place, so I recommend one.
This is a 100% recommended purchase. The game is a classic without a doubt, and all the demo needed to show was that it ran well, and it does. It really is a no-brainer. I hope more remakes like this one come for other previous console exclusives.