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Coelocanth: Did you try running it from nwn.exe instead of nwnmain.exe? What OS are you using?
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Suduki: Yes, I just tried that, both normally, in Windows XP (SP3) mode and in admin mode.
The launcher came up, clicked "Play", the NWN logo came up, vanished and then nothing.

And I'm using Windows 7 64-bit.
There is a 'safe mode' shortcut in NWN's folder n Start Menu. Can you launch the game from it?