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hal_wain: Is there any way to play this game in windowed mode?
In order to get windowed mode in the first Cultures you have to add the -window flag to the GOG shortcut so it looks something like this:

C:\GOG Games\Cultures and Cultures 2\Cultures\Cultures.exe -window

You'd then have to change the color depth to 16 bits.

Cultures 2, on the other hand, doesn't support a windowed mode, unfortunately :(