Is it worth installing it for a first playthrough or I am good with standard first?
Thanks!

I had tried it a while ago and as far as I'm concerned, no it's not worth it, particularly if you are concerned about disk space even a little bit.
There isn't a huge difference between the game with and without it and it weighs way too many GB.

Ok thanks LiefLayer

No!
Use these mods instead (they look way better and use less VRAM):
All Weapons HD (A.W.H.D.) (https://www.nexusmods.com/fallout4/mods/8556)
Better Handmade Weapon Textures (https://www.nexusmods.com/fallout4/mods/1372)
High Resolution Texture Pack 2K and 4K (https://www.nexusmods.com/fallout4/mods/318)
Vivid Fallout - All in One (https://www.nexusmods.com/fallout4/mods/25714)
Delightful Ivy - HD Vine Retexture (https://www.nexusmods.com/fallout4/mods/10436)
NMC's Texture Bundle (https://www.nexusmods.com/fallout4/mods/31814)
Eyewear and mask retexture (https://www.nexusmods.com/fallout4/mods/5021)
Fallout Texture Overhaul PipBoy (https://www.nexusmods.com/fallout4/mods/449)
FCO - HD Eyes (https://www.nexusmods.com/fallout4/mods/169)
Fallout Texture Overhaul Power Armors (https://www.nexusmods.com/fallout4/mods/3344)
WET - Water Enhancement Textures (https://www.nexusmods.com/fallout4/mods/20775)
Proto Vault Suit (https://www.nexusmods.com/fallout4/mods/2187)

Optional: Enhanced Blood Textures (https://www.nexusmods.com/fallout4/mods/212)
Optional: True Grass (https://www.nexusmods.com/fallout4/mods/23469)
Optional: Improved Map with Visible Roads + DLCs (https://www.nexusmods.com/fallout4/mods/1215)
Optional: Enhanced Lights and FX (https://www.nexusmods.com/fallout4/mods/13596)

I know the're way more Texturepacks on Nexus but these are all very "Lore-Friendly".

I will look into that, thanks igooseman

Any performance hit? I seem to recall that being an issue around the game's initial launch.

Not really. But VRAM-Usage is much higher (duh!).
If you run out of VRAM you should have framedops.
My GPUs had at least 11GB (now 24GB).
I have no experience with 6GB or 8GB-GPUs with Fallout 4.

These are just upscalled textures and are a little bit sharper than the vanilla-textures.
It's not worth the 60GB.

Comparison-Video
https://www.youtube.com/watch?v=YjVU91QEifk

If you have the VRAM (8 GBs at the very least, preferably 11GB+) and as others have mentioned, the extra 60GB of storage to spare, then yes its worth it if you don't want to hassle with mods. The vanilla textures are hideously low res, and if you play on 1440p or higher it is extremely noticeable. That said, the high res textures are still a mess, but a better looking mess than the ones originally released with the game.

I got brown faces when I used the High Res DLC. Because of that I stopped using that DLC years ago.

I think you need this:
Rusty Face Fix (https://www.nexusmods.com/fallout4/mods/31028)