Finally got a work around for win10 laptops.
Here we go...

Change pc setting
Go to display settings (right click desktop)
Click advanced display settings
Choose the display you are wanting to use and click display adapter properties for "display x"
On the color management tab click color management
Click the advanced tab and change viewing conditions profile to WCS profile for sRGB viewing conditions.

Ok.. with that done now go right click the shortcut to cultures and add -window to the end of the target line.
In compatibility mode select win xp sp2 and reduced color mode 16 bit.

After that launch from the shortcut and it should work in windowed mode. I'm still trying to figure out how to hook it with DXWnd so if anyone has an export file for it and could link it here that would be awesome. Lol

I don't need it but I think that the game could run flawesly with wrappers like ddrawcompat. Put the single dlli in the executable folder and it should run.

I have these games in CD versions and they work without problems on win7/10, so the GOG team has a problem with these versions and should fix them

Thank you! This actually worked very well for me for Cultures 2.

Just be sure to use the newest version of DDrawCompat (v0.4.0 as of the time I am writing this) of the wrapper if you have windows 11 since older versions won't work.