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I am running windows 10 64 bit Home and when I run the game I get an error message after the animations for the companies. In summary the message says that an instruction referenced that could not be read from and to click on OK to close. Is there any solution for this?
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First of - do restart. Alt+F4->Restart - exactly like that, no shutdown or hibenate.

There something wrong with addresses in RAM (not exist or no right to read-write). This can caused by game corruption, system or hardware. No guaranteed solution.

Try DEP solution from here:
[url=http://www.pcgamingwiki.com/wiki/Blood_Omen:_Legacy_of_Kain]http://www.pcgamingwiki.com/wiki/Blood_Omen:_Legacy_of_Kain[/url]
(manually add exe files for gaming tools and games or any program where DEP cause problems, there is solution to entirely disable it by CMD command, but entilery disabling is no recommended)

Check memory and system by two tools mentioned here:
http://answers.microsoft.com/en-us/windows/forum/all/explorerexe-error-the-instruction-0x00000000/90fcabb4-f947-4331-9836-e900d65e48fa

if you on Windows 8 or higher - check for latest stable updates\-builds. They are mandatory on that OS's (at same time bring a lot of troubles and fix them later). But before install DirectX (June 2010) and DirectX web-installers -> then go to Windows Control - Programs - Enable\disable Windows features - Legacy - Legacy DirectPlay.
Than check for updates, install and restart to apply directx changes.

Completely reinstall video driver(s). Try to add game exe manually to video driver Control panel and choose integrated or discrete GPU.
Set maximum power performance in Windows and video drivers.

if you use 3rd party antivirus disable it temporary.

Reinstall game to X:\Games\*Kain-1*\ (somethign without spaces, "_" non-latin letters and special symbols, short - and not in program files and better not to system drive at all)
Anyway set game exe admin run. This temporary partially disable Windows Defender for that exe and all further, but Defender can keep looking at game folder (and 100% keep look at Program Files).

Did you use GOG Galaxy to install game or offline installer? Same rules to Galaxy +something more. For offline version just reinstall, while for any online distribution reinstalling do nothing. Validate. Twice. After every downlaoding.
Post edited February 12, 2022 by QWEEDDYZ
I did use GOG galaxy to install it, and I'm using windows 10 as stated in my original post
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wrace0: Just use Verok's mod.

It seems that gog did not fix all problems of this game (as usually) though the appropriate solution was created at least in 2008 and it is used now in Verok's mod too.
If this is DEP issue it also happen to verok's moded version (with black screen). Same for RAM\OS brokeness.

GOG version should start and at least barely work. Completely not working - is something absolutely unnormal and unusual. If it game client brokeness (always do verify game files in any downloading programs) - verok mod also be posibly broken (data folder been replaced by mod, so only if exe corrupted).
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wrace0: Oh, yeah. The original exe (which is not corrupted by gog) can be taken here.

There are 3 cases:
1) some problems on PCs with activated for all files DEP and/or activity of some antivirus due to bad hands of gog which corrupted the main exe file - in such case one need to use the original exe file instead of corrupted by gog file;
2) the absence of some patches - in such case one needs to use Verok's mod;
3) corrupted pill.big - it should have the size 163,998,755 bytes.
All other files do not matter at all (just cinematics and sound of them).

P.S.: exactly, Message Box provides the address of the error and it is not problem to check what is wrong with the knowledge of the address which was not provided by TS.
I applied the Verok's mod but as well as making sure the settings for when to use DEP were correct and still the same result. I think you may have found the problem because PILL.BIG is showing 160,156 KB
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wrace0: In such case reinstall the game while you will obtain pill.big of the correct size.
On the Steam there are no problems with this at all and there is a possibility to verify the game's integrity.
P.S.: yes, I know that BO1 is on gog only now, but it is due to stupid and lazy publisher (Square Enix).
Did that a few times, I can try it again. Worse case I will bug gog for a refund if It doesn't work. I already have a help ticket with them that they have yet to give me any answer other than high problem volume, and they will address it ass soon as they can
You always can get a refund from GOG if the game dont work for you. But this take some time.

Try offline version.
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wrace0: RetroCynthia, since you already bought BO1, so I can provide for you its original files: download archive from here and extract its contents into new empty folder (for example, BO1) in the root of the drive C: (or D: if you have it).

It is mini version of the game with mini version of Verok's mod.
If it will work, just download full version of Verok's mod and extract its contents into this new game folder.
If it will not work, provide screenshot of the Message Box with error (I need the address of crash from it).

P.S.: do not forget to write post here when you will download archive I provided for that I can remove it from G-Drive.
Thank you for the help, I just got it downloaded. sorry it took me bit, I was applying to jobs and going through interviews. I will let you know if it works

EDIT: It worked, and applied Verok's mod. Thank you sooo much!!! Still waiting for GOG to email me about the issue so I'm happy to have a working copy
Post edited February 23, 2022 by RetroCynthia
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wrace0: No problems. To all who will have any problems with this game:
1) take the original pill.big (hm, find by yourself or ask me);
2) take the original kain.exe (from The Lost Worlds);
3) take the Verok's mod (from his blog).
Such game must work on any PC with any new OS (Win-10/11/...).
GOG differences is exe only file (+help, manual). KAIN\KAIN\ sub-folder is identical.

There is no issue with GOG's version (new exe use also differ SAVED folder Saves and + Cfg folder with some settings (same for GL mod and this cfg files are referred in original EXE file).
Out of curiosity, has anybody tried this on a SteamDeck using the Heroic Games Launcher?
I can get it installed, but I run into the same issue as the OP described: crash after the logo animations.
I haven't been able to get Verok's version running under Lutris either - the install just hangs instead of creating any files.
Since this is Linux and third party apps issue, i dont think someone in near future able to help you here.

Since it still some apps possible to interfere even on Stam Deck (especially on Steam Deck?), try to close as much possible un-needed applciations.There ones with overlay and there is ones with hiden overlay injected to games.

Probably this game cant work on Steam Deck... check PCGW article and links to ProtonDB\WindeDB sites from there to see about Linux tweaks for this game
[url=http://www.pcgamingwiki.com/wiki/Blood_Omen:_Legacy_of_Kain]http://www.pcgamingwiki.com/wiki/Blood_Omen:_Legacy_of_Kain[/url]

Probably this launcher you use cause your problem. There is chance for it. This game probably more than others games dont like such apps if they have overlay.

Initial OP problem can be also from anything. Such many tweaks, such bad Windows back compatibility, bad Windows quality (tweak not cause a old game).
And GOG who put unneeded compatiblitys to every exe's on every OS.

So first of - install game on Widnwos OS, back up game fdler from installed GOG - uninstall optionally and move game folder to new place\PC-Win\PC-Lin\Steam_Deck.
Use offline installer and updated one (more changes to game exe) - check digital siganture of exe file, it should be Oct 7 '21 for file setup_blood_omen_legacy_of_kain_1.0_hotfix_(50549)
no galaxy_blood_...*.
Post edited April 09, 2022 by QWEEDDYZ