Game balance has always been an issue in Arcanum. You'll run into that with Gunsmithing internally.
1) Intelligence is going to be a major stat for you, topping at 19 if you want to run any discipline to its conclusion. Therefore you'll want to consider picking skills which are dependent on Intelligence. There aren't many, and not all are universally useful, but it's definitely worth considering. To my knowledge, this is only Heal, Repair and Gambling.
I enjoyed playing a gambler, but it's simply not necessary for anything, and nobody will gamble with you after you win a few times against them. (One possible exception, and even he puts up a fuss.) Repair becomes somewhat useful when you train it to the max, and Heal becomes more useful to a technologist than to a mage.
2) A very high intelligence is prerequisite for certain dialogue options, but so too is a high Persuasion (and therefore high Charisma.) If you wish to take advantage of some of these dialogue options, you'll need to build a character capable of reaching those plateaus, perhaps even topping out Persuasion. Alternatively, if you wish for a less diplomatic game, you might consider Charisma something of a 'dump stat' just to help you resist the temptation.
3) While you can't go wrong with a touch of melee, I can tell you that, with a competent party, I took a physically weak technologist clear through the end of the game without a single dot in Explosives or Melee. It helped that I knew where I was going and what I was doing, but nevertheless it's quite possible. I even got my pick of the endings if I so chose.
4) I think the comma key ( , ) might be for headshots. Can't recall for certain. I know I used it a lot with her.
5) The Hand Cannon is an excellent gun even in the late game and the guns immediately following it simply don't surpass it. If you wish to run gunsmithing to its most impressive conclusion, be prepared for a few disappointing guns before you get to the bigger buggers at the end.
6) None of your followers will every be truly good at anything. Not really. If you want something of good quality or high level, you have to do it yourself. Combat, maybe, you can foist off on others. (Especially the dog. Look up the dog. You may or may not wish to worry about him as a party member, as he's a bit of an experience hog, but you only get one chance to save his life.)
7) Try not to worry too much. Do what's fun. My advice here is to help you pick the things which allow you to have fun with the least pain or difficulty.