I just downloaded the first Van Helsing and got a Nvidia PhysX setup popping up at the end of the installation. You have to install the PhysX driver, even if you have an AMD GPU. And now the important part: I know at least two popular game series that install PhysX on AMD systems too (Metro and Borderlands), so there's a good chance you already have PhysX installed on your system! In this case, PhysX won't install and Galaxy won't finish the setup! To make things even worse, you don't even get any helpful information on what happened. On my German system (maybe it's different on English language systems) I got a PhysX popup saying "Text" (<- No joke!) and a cancel button.

I tried starting the game through the exe in the game folder (without Galaxy running, since it still wanted to install PhysX) and got stuck on the loading screen. Since I knew this problem already from Borderlands and Metro, I knew how to solve it. You have to shut down Galaxy (or the setup if you downloaded the standalone installer) go to the installed programs in your control panel, find the "NVIDIA PhysX" entry, uninstall the drivers and restart Galaxy or your installer. PhysX will install correctly now. Congratulations, you're now allowed to play your game! ;P

Just thought I'll drop this here since I've seen many AMD users who had problems playing Metro and Borderlands due to this problem.