To address your comment about uninstallation—if you followed my guide then I have no idea ;)
It's never asked me to uninstall when running the game.
But it's easy to make a mistake during installation. Are you sure you fully followed Step 7
and selected "Vampire.exe"
from the dropdown? You may have accidentally selected (or it likely defaulted to) the uninstaller executable instead. If so, you can go back and set the correct EXE path from the advanced wineskin window. If you followed the guide's app title and location, it should be at "/Applications/Vampire the Masquerade - Bloodlines.app/drive_c/GOG Games/VtMB/Vampire.exe"
As to your other question, about the the left mouse button not working. There's a common bug where a new game won't load the character hands and weapons, so clicking to attack does nothing. I've run into this issue primarily when trying to play a Tremere, but I've seen it occur for other clans as well.
The most common solution to the issue is simply to wipe the save and start a new game, but on occasion I haven't been able to get my Tremeres to properly load even after numerous restarts. In such case, you can use console commands to load up your hands and prep your character for interaction (you'll need to enable the in-game console by adding the EXE Flag "-console" via Step 8
of my install guide). You can load up the console by hitting the tilde (~) key. Console Commands to fix the "no hands" issue
• give item_w_unarmed
• give item_w_fists
• give weapon_physcannon
There are a lot of different potential startup script glitches. People also occasionally report missing their wallet, keyring, clothes, etc. So in case you find any of those missing, their respective console commands are:
• give item_g_wallet
• give item_g_keyring
• give item_a_lt_cloth
I hope some of that helps :)